Journal of the American Society of Echocardiography
Pre-Clinical InvestigationSeptal Ablation Induced by Transthoracic High-Intensity Focused Ultrasound in Canines
Section snippets
HIFU Apparatus for Transthoracic Septal Ablation
The model JC200 HIFU tumor therapeutic system (Chongqing Haifu Technology Co. Ltd., Chongqing, China) was used. This system includes the following components: an ultrasound therapeutic transducer, an ultrasound imaging unit, a degassed water circulation unit, a motion unit, an operator console, and an ultrasound signal generator (Figure 1). The therapeutic transducer has a diameter of 22 cm, a focal length of 148 mm, and an operating frequency of 1.03 MHz. The acoustic focal region is an
Overall Procedural Considerations
Each dog received an artificial hydrothorax without obvious complications. No vital sign disturbances were observed. The artificial hydrothorax successfully improved the ultrasound transmission (Figure 4). All of the canines, except five from group C, underwent HIFU-induced ablation and were maintained with normal respiratory rhythm, appetite, and activity level. The canines in group C were sacrificed because of the tamponade caused by retrieving the optic fiber after the temperature
Discussion
Our results demonstrated that cardiac septal ablation could be achieved and extended using transthoracic ultrasound-guided HIFU in canines. The lesions displayed full coagulation necrosis with a clear boundary that distinguished the surrounding normal tissue. In addition, no significant injuries were observed in the surrounding tissues near the target or along the acoustic path.
Conclusions
Ultrasound-guided transthoracic HIFU has the potential to safely create small dot or large mass lesions in the septum without a thoracotomy or a catheter. These findings suggest that transthoracic HIFU may be developed as an alternative noninvasive, nonradiation strategy for intramyocardial ablation.
Acknowledgments
We thank Professor Shunhe Wang from the Department of Pathology at Chongqing Medical University for advice on the histologic analysis. We thank Dr. Rong Jiang from the Department of Histology and Embryology at Chongqing Medical University for technical support for the tissue preparations and histologic analysis.
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2018, IRBMCitation Excerpt :The probe was mounted on a three-dimensional positioning system to target the different parts of the organ because of the absence of dynamic focusing. Newer experiments confirmed these results with equivalent methods and were able to successfully generate septal ablation [56] and complete heart block [57]. While it could be considered as the least invasive HIFU technique, there are few current applications of this thermal method of HIFU.
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This work was supported in part by research grants from the National Natural Science Foundation of China (30527001 and 30830040), the National Key Basic Research Program of China (973 Program, 2011CB707902), and the Foundation for Key Scientific and Technical Research of Chongqing, China (CSTC2005AA5008-5 and CSTC2009AB5003). Zhibiao Wang is a shareholder in Chongqing Haifu and a professor in the Department of Biomedical Engineering of Chongqing Medical University, Chongqing, China.