Original ArticleTelomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study☆
Under a Creative Commons license
open access
Graphical abstract
Keywords
Endothelial dysfunction
Telomere lengths
Telomere G-tail lengths
White matter changes
Cited by (0)
- ☆
Research in context: Telomere length is considered a biomarker of human aging; specifically, an indicator of cellular senescence and atherosclerosis. Recently, the telomere G-tail, which is an extension of the guanine-rich single-stranded 3′-overhang, has been identified as a key structure that protects telomere DNA from DNA damage. We found that telomere G-tail length might be superior to total telomere length as a marker of endothelial dysfunction and age-related white matter changes among patients with cardiovascular risk factors. These factors are responsible for dementia, stroke and disability. We hope that our findings will be suitable for use in general populations.
Copyright © 2015 The Authors. Published by Elsevier B.V.