Antimicrobial Susceptibility Study
NDM-1 encoded by a pNDM-HN380-like plasmid pNDM-BJ03 in clinical Enterobacter cloacae

https://doi.org/10.1016/j.diagmicrobio.2017.10.022Get rights and content

Highlights

  • Isolation of an Enterobacter cloacae hhy03 from a patient.

  • A resistant plasmid pNDM-BJ03 from E. cloacae hhy03 was sequenced and analyzed.

  • pNDM-BJ03 harboring blaNDM-1 and blaSHV-12 is similar to pNDM-HN380.

  • Indicate that NDM-1 can be transmitted by IncX3 plasmid between Enterobacteriaceae.

Abstract

A carbapenemase-producing Enterobacter cloacae hhy03 with a blaNDM-1 and blaSHV-12-coharboring plasmid was isolated from a sputum specimen of a patient. This is the third nucleotide sequence report of blaNDM-1-harboring plasmid from Enterobacter cloacae that have caused lethal infections in China, indicating the spread of NDM-1 by IncX3 plasmid between Enterobacteriaceae.

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Conflicts of Interest

The authors declare no competing interests.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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These two authors contributed equally to this work.

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