VirologyCharacteristics of the cellular immune response in HIV/HCV patients with hemophilia during peginterferon/ribavirin therapy in southern China☆,☆☆
Section snippets
Background
Hepatitis C is a major cause of morbidity and death in HIV-infected individuals (Bambha et al., 2012, Mocroft et al., 2012). As reported, 9–40% HIV patients are co-infected with hepatitis C virus (HCV) (Greub et al., 2000), and HCV infection rate reaches 85% in HIV patients with hemophilia (Sterling et al., 2010). Co-infection with HIV accelerates the progression to liver cirrhosis. Cellular immune responses, crucial for the control of HCV infection (Rohrbach et al., 2010), are weak in chronic
Patients
Thirty-six HIV/HCV co-infected patients with hemophilia in Shanghai Public Health Clinical Center from 2007 to 2009 were enrolled in this study, their ages ranging from 19 to 51 years old, sex ratio of 1:1, all the patients were HBV DNA negative and infected with HCV genotype 1b.
Clinical characteristics of the study group are described in Table 1. Age and ethnicity were similar among the patient groups.
All patients were treated by combined antiviral therapy for HCV. They were given
Patient characteristics and SVR
Thirty-six HIV/HCV co-infected patients with HCV genotype 1 had SVR rate of 27% (10/36) compared to 45% in mono HCV genotype 1 infected group. SVR in HIV/HCV co-infected patients was not associated with the immune state and CD4+ cell counts of patients; it increased with inflammatory scores of liver histology but had no obvious correlation (P > 0.05). SVR rate in IL28B genotype CC is 41% (7/17); it is much higher than that (16%, 3/19) in genotype non-CC in HIV and HCV genotype 1 co-infected
Discussion
In HCV monoinfection, combination antiviral therapy has resulted in SVR rates ranging from 45% to 55% in groups with genotypes 1 or 4 (François et al., 2009). In HCV/HIV co-infection, SVR rates in patients infected with genotype 1 are lower than those infected with genotype 2 or 3.
The incidence of hemophilia is higher than 85% in HIV/HCV co-infected patients, and it is necessary to give combination antiviral therapy for HCV to these patients. In China, the most common genotypes of HCV infection
Acknowledgment
This work was supported by Fudan University, China.
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Cited by (2)
Influence of IL28B gene polymorphisms on PegINF-RBV-mediated HCV clearance in HIV-HCV co-infected patients: A meta-analysis
2021, Meta GeneCitation Excerpt :The research articles were further stratified according to the SNPs, HCV genotypes, and treatment response (SVR/RVR). There were 34 and 12 studies that examined the association of IL28B rs12979860 with SVR (Abu Dayyeh et al., 2011; Amorosa et al., 2013; Bruno et al., 2015; Corchado et al., 2014; de Castellarnau et al., 2012; Di Lello et al., 2013; Franco et al., 2014; Keane et al., 2013; Labarga et al., 2014, Labarga et al., 2012, Labarga et al., 2011; López-Cortés et al., 2012; Mandorfer et al., 2013b, Mandorfer et al., 2013a; Matas and Picornell, 2014; Mira et al., 2012; Nattermann et al., 2011; Neukam et al., 2013b, Neukam et al., 2013a, Neukam et al., 2012; Osinusi et al., 2012; Pineda et al., 2010; Rallon et al., 2013, Rallon et al., 2012; Rallón et al., 2011, Rallón et al., 2010; Antonio Rivero-Juarez et al., 2013b; A. Rivero-Juarez et al., 2013b; Sehgal et al., 2014; Stenkvist et al., 2013; Sticchi et al., 2015; Torres-Cornejo et al., 2014; Vispo et al., 2012; Yingying et al., 2014; Zeremski et al., 2013) and RVR (Corchado et al., 2014; Keane et al., 2013; López-Cortés et al., 2012; Mandorfer et al., 2013a; Matas and Picornell, 2014; Neukam et al., 2013a; Rallón et al., 2011; Antonio Rivero-Juarez et al., 2013b; Rivero-Juarez et al., 2012; Rivero-Juárez et al., 2012; Stenkvist et al., 2013; Torres-Cornejo et al., 2014), respectively, for all the HCV genotypes. The studies that evaluated the association between the other SNPs and SVR are as follows: 6 studies for rs8099917 (Aparicio et al., 2010; Bruno et al., 2015; de Castellarnau et al., 2012; Fernández-Rodríguez et al., 2013; Liu et al., 2015; Sticchi et al., 2015), and 4 studies for rs12980275 (Fernández-Rodríguez et al., 2014, Fernández-Rodríguez et al., 2013; Guzmán-Fulgencio et al., 2014; Pineda-Tenor et al., 2014). (
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Competing interests: The authors declare that they have no competing interests.
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Authors' contributions: LY designed the experiment and drafted the manuscript. WJR collected the specimen and performed the statistical analysis. LJ carried out most experiments and participated in its design. All authors read and approved the final manuscript.