Developmental Cell
Volume 21, Issue 6, 13 December 2011, Pages 1005-1013
ArticlePrimitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling
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Graphical Abstract
Highlights
► Nanog knockdown is sufficient to specify primitive endoderm cell autonomously ► Nanog induction of Fgf4 contributes to PrE maturation in neighboring cells ► Early Gata6 expression is directly RTK dependent ► Late Gata6 expression is indirectly RTK dependent via repression of Nanog
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These authors contributed equally to this work
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Present address: Department of Zoology, University of Melbourne, 3010 Victoria, Australia
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Present address: IGF, CNRS UMR5203, INSERM U661, University of Montpellier I and II, 34095 Montpellier Cedex, France
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