Current Biology
Volume 21, Issue 4, 22 February 2011, Pages R162-R163
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Split Genes: Another Surprise from Giardia

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Summary

Some genes in the candidate early-branching eukaryote Giardia lamblia occur in separate pieces, transcribed from non-contiguous chromosomal locations. The pre-mRNAs from the separate pieces apparently find each other by regions of complementarity and are subsequently spliced together by the spliceosome. Could genes in pieces, transcribed into separate pre-mRNAs, have been an early feature of spliceosomal evolution?

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