Current Biology
Volume 17, Issue 13, 3 July 2007, Pages R514-R516
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C. elegans Aging: Proteolysis Cuts Both Ways

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Recent reports from two laboratories working on the nematode Caenorhabditis elegans have identified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of longevity by the insulin/insulin-like growth factor signaling pathway.

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