Elsevier

Computers in Biology and Medicine

Volume 64, 1 September 2015, Pages 91-100
Computers in Biology and Medicine

Quantitative breast mass classification based on the integration of B-mode features and strain features in elastography

https://doi.org/10.1016/j.compbiomed.2015.06.013Get rights and content

Highlights

  • Quantitative strain features wereextracted fromelastographic images to express tissue elasticity.

  • A computer-aided diagnosis system based on the quantitative strain features was developed to classify breast masses.

  • Combining the strain features with the B-mode features obtained a significantly better performance in malignancy evaluation.

Abstract

Background

Elastography is a new sonographic imaging technique to acquire the strain information of tissues and transform the information into images. Radiologists have to observe the gray-scale distribution of tissues on the elastographic image interpreted as the reciprocal of Young׳s modulus to evaluate the pathological changes such as scirrhous carcinoma. In this study, a computer-aided diagnosis (CAD) system was developed to extract quantitative strain features from elastographic images to reduce operator-dependence and provide an automatic procedure for breast mass classification.

Method

The collected image database was composed of 45 malignant and 45 benign breast masses. For each case, tumor segmentation was performed on the B-mode image to obtain tumor contour which was then mapped to the elastographic images to define the corresponding tumor area. The gray-scale pixels around tumor area were classified into white, gray, and black by fuzzy c-means clustering to highlight stiff tissues with darker values. Quantitative strain features were then extracted from the black cluster and compared with the B-mode features in the classification of breast masses.

Results

The performance of the proposed strain features achieved an accuracy of 80% (72/90), a sensitivity of 80% (36/45), a specificity of 80% (36/45), and a normalized area under the receiver operating characteristic curve, Az=0.84. Combining the strain features with the B-mode features obtained a significantly better Az=0.93, p-value<0.05.

Conclusions

Summarily, the quantified strain features can be combined with the B-mode features to provide a promising suggestion in distinguishing malignant from benign tumors.

Introduction

As an adjunct to mammography, ultrasound (US) is widely used in distinguishing between benign and malignant breast lesions [1]. The Breast Imaging Reporting and Data System (BI-RADS) lexicon for US was defined by American College of Radiology [2] to standardize the descriptive terminology. The sonographic descriptors defined in BI-RADS lexicon such as shape, orientation, margin, lesion boundary, echo pattern, and posterior acoustic features were evaluated to be important in classify breast lesions in the prior studies [3], [4], [5]. With the standardized BI-RADS descriptors, the radiologists improved their agreement and performance in US interpretation across all experience variables in the literature [5].

After quantification, the sonographic descriptors were used in various computer-aided diagnosis (CAD) systems to estimate the likelihood being a carcinoma [6], [7], [8]. The quantitative characteristics extracted from B-mode images such as shape features were used in describing the physical properties of breast tumors [9], [10]. The mechanical property of tumors is also investigated for histological and pathological relevance. For example, the pathological changes of the scirrhous carcinoma correlate with tissue stiffness [11]. As a newly developed sonographic imaging modality [12], [13], [14], elastography estimates the tissue stiffness by calculating the tissue displacement under a certain force. In quasi-static elastography, the tissue displacement is induced by manual pressing on the transducer such as the respiratory movement of patients utilized in this study. As another form of elastography, shear wave elastography [15], automatically radiates shear waves inside tissues and reconstructs the elasticity properties of tissues from the propagated shear wave. However, the simplicity of quasi-static elastography makes it can be implemented using conventional US hardware.

The gradient of the displacement or strain is converted to the pixel value for imaging. Clinically, the size ratio between the strain area in elastographic images and tumor area in B-mode images was evaluated to interpret breast tumor malignancy [16], [17], [18], [19], [20]. The definition is the maximum horizontal length of the tumor measured in the elastographic image divided by the corresponding length measured in the B-mode. A tumor with an elastographic images/B-mode size ratio greater than 1.0 had high likelihood being malignant. The stiffness contrast and normalized shear strain area were also used to diagnose breast tumors [14], [19], [21], [22], [23], [24]. The stiffness contrast is the ratio between the mean strains estimated in the background to that estimated within the breast tumor. The area obtained from the strain area can be normalized via the tumor size measured from the B-mode image. The performances of Az, area under the receiver operating characteristic (ROC) curve achieved 0.84–0.99 in the results of the literature.

However, by observing the elastographic images, the shape and boundary of tumor area are not as clear as those in B-mode images. Radiologists have to manually compare elastographic images and B-mode images to estimate the stiffness of tumor area which is operator-dependent. Burnside et al. indicated that inter-observer variability was an influence factor to the diagnostic performance [17]. Prior CAD approach which extracted quantitative elasticity features from acoustic radiation force impulse imaging achieved an accuracy of 80% in classifying breast tumors [25]. In this study, we proposed an automatic procedure to extract strain features from quasi-static elastography in a CAD system for tumor classification. Tumor segmentation was first applied to the B-mode images and the resulting tumor contour was mapped to the elastographic image. The fuzzy c-means clustering (FCM) [26] was then used to automatically extract stiff tissues with darker values for feature extraction. Compared to other CAD systems [6], [7], [8], [9], [10], the current study explored the performance difference between the quantitative strain features and B-mode features. The complementary advantage of combining both feature sets was also evaluated in the experiment. The flowchart of the diagnostic procedure is shown in Fig. 1.

Section snippets

Patients and data acquisition

This study obtained the approval from our institution review board and the patients׳ informed consent. A total of 90 patients underwent ultrasound examination with an ACUSON S2000 ultrasound system (Siemens Medical Solutions, Mountain View, CA) from November 2011 to June 2012. The equipped linear-array transducer was a 9L4 for the B-mode sonographic examination followed by elastography imaging. The target lesion was displayed in the B-mode sonogram with the corresponding strain image displayed

Results

Table 1 shows the test result of the proposed six strain features. Only one of them was not significant. In Table 2, the B-mode feature set included 15 significant features such as the best-fit ellipse properties and NRL features. The performances of the feature sets using the binary logistic regression model are shown in Table 3. The proposed strain feature set achieved an accuracy of 80% (72/90), a sensitivity of 80% (36/45), a specificity of 80% (36/45), and an Az of 0.84. In the comparisons

Discussion

This study proposed a CAD system to extract quantitative strain features from elastographic images for breast mass classification. With the mapping of tumor contour from the B-mode image, the tumor area in the elastographic image can be specified automatically to reduce user dependence. After FCM clustering, the stiff tissues surrounding the tumor area were extracted to estimate the size of strain area. The one-dimension strain length and two-dimension strain area around a tumor were calculated

Conclusion

This study proposed an automatic procedure to extract strain features from elastographic images with less operator dependence. The quantified strain features can be integrated with the B-mode features in the CAD system to provide a promising diagnosis of breast tumors.

Summary

Conventionally, radiologists have to observe the gray-scale distribution of tissues on the elastographic image to acquire the strain information of tissues. This study proposed a computer-aided diagnosis (CAD) system to extract quantitative strain features from elastographic images to reduce operator-dependence and provide an automatic procedure for breast mass classification. For each breast mass, tumor segmentation was performed on the B-mode image to obtain tumor contour which was then

Conflict of interest statement

None declared.

Acknowledgments

The authors thank the National Science Council (NSC 101-2221-E-002-068-MY3), Ministry of Economic Affairs (100-EC-17-A-19-S1-164), Department of Health (DOH102-TD-C-111-001), and Ministry of Education (AE-00-00-06) of the Republic of China for the financial support.

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