Cell Metabolism
Volume 10, Issue 3, 2 September 2009, Pages 161-162
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Getting a “Hold” on NPC2

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Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

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