Review article
Updated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy

https://doi.org/10.1016/j.cjtee.2017.03.004Get rights and content
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Abstract

Uncontrolled hemorrhage and subsequent trauma-induced coagulopathy (TIC) are still the principle causes for preventable death after trauma and early detection and aggressive management have been associated with reduced mortality. Despite increasing knowledge about trauma resuscitation, best practice to treat this newly defined entity is still under debate. A synopsis of best current knowledge with reference to the updated European trauma guideline on the management of severe trauma hemorrhage and TIC is presented. The implementation of evidence-based local protocols and algorithms including clinical quality and safety management systems together with parameters to assess key measures of bleeding control and outcome is advocated.

Keywords

Hemorrhage
Blood coagulation disorders
Hemostatics
Blood transfusion

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Peer review under responsibility of Daping Hospital and the Research Institute of Surgery of the Third Military Medical University.