Chemistry & Biology
Volume 18, Issue 2, 25 February 2011, Pages 144-145
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Chemically Targeting the Emergent Properties of a Chaperone Complex

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In this issue, Chang et al. (2011) report a small molecule screen against the reconstituted DnaK-DnaJ-GrpE chaperone cycle. Through this approach, they identified myricetin as an inhibitor of DnaJ-stimulated DnaK ATPase activity, indicating the potential for their screening approach to identify modulators of emergent properties of protein complexes.

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