Cell Reports
Volume 17, Issue 6, 1 November 2016, Pages 1621-1631
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Article
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

https://doi.org/10.1016/j.celrep.2016.10.020Get rights and content
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Highlights

  • Ovarian and uterine cancers have variable hyperthermia sensitivities

  • CTGF promotes hyperthermia resistance

  • Targeting CTGF can sensitize cancers to hyperthermic therapy

  • In vivo hyperthermia by copper sulfide nanoparticle-based technology

Summary

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Keywords

hyperthermia
ovarian cancer
CTGF
DOPC-liposome
thermosensitivity
copper sulfide nanoparticle

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Present address: Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan

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