Cell
Volume 141, Issue 7, 25 June 2010, Pages 1114-1116
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D'oh! Genes and Environment Cause Crohn's Disease

https://doi.org/10.1016/j.cell.2010.06.015Get rights and content
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Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases by identifying genes that predispose individuals to these disorders. Cadwell et al. (2010) now demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility gene collude to cause inflammatory disease in the mouse gut.

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