Elsevier

Cell Calcium

Volume 92, December 2020, 102289
Cell Calcium

Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis

https://doi.org/10.1016/j.ceca.2020.102289Get rights and content

Highlights

  • TPC1 knockout mice display enhanced allergic responses in vivo.

  • TPC1 knockout enhances degranulation in mast cells.

  • TPC1 knockout enhances ER Ca2+ content and Ca2+ release.

Abstract

The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca2+ mobilising messenger NAADP and the phosphoinositide PI(3,5)P2. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca2+ release and secretion in mast cells.

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Funding

This work was funded by the BBSRC (grants BB/N01524X/1 and BB/T015853/1 to SP)

References (10)

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