Cancer Cell
Volume 19, Issue 1, 18 January 2011, Pages 86-100
ArticleEZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling
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Highlights
► Increased EZH2 expression in BTICs enhances BTIC survival and proliferation ► EZH2-amplified RAF1-β-catenin signaling promotes BTIC expansion ► Hypoxic microenvironment promotes BTICs through upregulating EZH2 expression ► AZD6244 suppresses BTICs by inhibiting activated RAF1-ERK-β-catenin signaling
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Present address: Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
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