Cancer Cell
Volume 31, Issue 5, 8 May 2017, Pages 607-608
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A TIAM Double Hit to Oppose YAP/TAZ

https://doi.org/10.1016/j.ccell.2017.04.009Get rights and content
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In this issue of Cancer Cell, Diamantopoulou et al. uncover dual mechanisms of inhibiting YAP/TAZ by TIAM1 that oppose invasiveness of colorectal cancer cells: TIAM1 interacts with TAZ in the cytoplasm to promote TAZ degradation by the destruction complex, whereas it antagonizes binding of TAZ/YAP to TEAD in the nucleus.

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