Modification and cross-linking parameters in hyaluronic acid hydrogels—Definitions and analytical methods
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Highlights
► We define terms describing cross-linked HA hydrogels. ► A novel method for the analysis of cross-linker ratio of HA hydrogels is introduced. ► The method is applied on two different HA hydrogels.
Abbreviations
MoD
degree of modification
DS
degree of substitution
CrD
degree of cross-linking by stoichiometric relationship
DC
degree of cross-linking by fraction cross-linked monomer units
CrR
effective cross-linker ratio
Keywords
Hyaluronan
Hydrogel
Degree of cross-linking
Effective cross-linker ratio
Degree of modification
Characterization
Determination
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Present address: Swedish Match AB, Stockholm, Sweden.
Copyright © 2012 Elsevier Ltd.