Short communicationAge-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats
Section snippets
Acknowledgements
This work was supported by Korean Ministry of Health and Welfare Research Foundation Grant (0405-NS01-0704-0001). This study was supported in part by year 2004 BK21 project for Medicine, Dentistry and Pharmacy.
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Cited by (20)
Oxidative stress induces the decline of brain EPO expression in aging rats
2016, Experimental GerontologyErythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer's disease
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Additionally, single doses of Epo improve CA1 neural density and Morris water maze performance deficits induced by hypoxic–ischemic brain injury (Kumral et al., 2004). Moreover, there is increasing evidence, suggesting that age related decreases of Epo expression in the hippocampal region may contribute to AD (Chung et al., 2004). The LTP in the hippocampus is the common model for studying the learning and memory processes (Bliss and Collingridge, 1993).
Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus
2007, Neurobiology of DiseaseCitation Excerpt :Epo is barely detectable in the adult hippocampus by western blot analysis in basal conditions (Ehrenreich et al., 2005). Our in situ study agrees with a prior work (Chung et al., 2004) showing that Epo is mainly localized in pyramidal neurons, hilar neurons and granule cells. Here, we also show that few astrocytes express Epo.
Erythropoietin treatment improves neurological functional recovery in EAE mice
2005, Brain ResearchCitation Excerpt :This functional benefit was paralleled with decreases of inflammatory infiltrates and demyelination of the CNS, and enhanced neurogenesis and BDNF expression. EPO possesses biological activities in addition to the erythropoietic effects that originally provided its name [1,4,6,7,9,10,24,27,29,33,35]. Many cell types produce EPO and many cells besides erythroid progenitors express the EPO-R, including cells in the brain [11,24].