Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Archival ReportObsessive-Compulsive Symptoms Among Children in the Adolescent Brain and Cognitive Development Study: Clinical, Cognitive, and Brain Connectivity Correlates
Section snippets
Overview
The ABCD Study is a multisite study (21 sites across the United States) with the overall goals of 1) assessing variability in adolescent brain and cognitive development and 2) understanding factors that influence development (34). Using a school-based recruitment strategy (public and private elementary schools), the ABCD Study has collected baseline clinical, questionnaire, behavioral, and neuroimaging data from 9- and 10-year-olds with ongoing longitudinal assessments (35). Exclusion criteria
Participants
Tables 1 and 2 summarize demographic and clinical characteristics of the full sample and compare them by K-SADS OCD diagnosis (Tables S2 and S3 compare by OCS score ≥5). A total of 1099 children (9.41%) had a lifetime parent-reported diagnosis of OCD, including 898 current (7.68%) and 501 past (4.29%). Lifetime OCD prevalence varied by site (χ221 = 59.29, p < .001) from 5.79% to 13.77%. Yet, site differences (n = 10,137, F21 = 1.49, p = .07) were largely accounted for by our demographic
Discussion
We leveraged the large normative ABCD Study dataset to probe OCSs among 9- and 10-year-old children across the United States. Complex associations with cognitive performance were detected: Specifically, higher OCS scores were related to better cognitive performance, particularly verbal, only when covarying for ADHD. Although we did not detect associations with brain structure, OCS scores did relate to differences in structural and functional connectivity of corticostriatal and attentional
Acknowledgments and Disclosures
Data used in the preparation of this article were obtained from the ABCD Study (https://abcdstudy.org), held in the National Institute of Mental Health Data Archive. The ABCD Study is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041022, U01DA041028, U01DA041048, U01DA041089, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123, and U24DA041147. A full list of supporters is available at //abcdstudy.org/nih-collaborators
References (104)
- et al.
Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
J Psychiatr Res
(2015) - et al.
Obsessive compulsive disorder in adolescence: An epidemiological study
J Am Acad Child Adolesc Psychiatry
(1988) - et al.
The epidemiology of obsessive-compulsive disorder in Spanish school children
J Anxiety Disord
(2012) - et al.
Frequency of obsessive-compulsive disorder in a community sample of young adolescents
J Am Acad Child Adolesc Psychiatry
(1994) - et al.
Genetic and environmental contributions underlying stability in childhood obsessive-compulsive behavior
Biol Psychiatry
(2007) - et al.
Neuropsychological functioning in a subclinical obsessive-compulsive sample
Biol Psychiatry
(1999) - et al.
Response inhibition in a subclinical obsessive-compulsive sample
J Behav Ther Exp Psychiatry
(2015) - et al.
A computerized neuropsychological evaluation of cognitive functions in a subclinical obsessive-compulsive sample
J Behav Ther Exp Psychiatry
(2018) - et al.
Brain structural correlates of subclinical obsessive-compulsive symptoms in healthy children
J Am Acad Child Adolesc Psychiatry
(2018) - et al.
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
Psychiatr Clin North Am
(2000)
Obsessive-compulsive disorder: Beyond segregated cortico-striatal pathways
Trends Cogn Sci
Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: A meta-analysis of resting-state functional connectivity
Neurosci Biobehav Rev
Large-scale brain networks and psychopathology: A unifying triple network model
Trends Cogn Sci
Fronto-striatal dysfunction during decision-making in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder
Biol Psychiatry Cogn Neurosci Neuroimaging
The conception of the ABCD Study: From substance use to a broad NIH collaboration
Dev Cogn Neurosci
Recruiting the ABCD sample: Design considerations and procedures
Dev Cogn Neurosci
Demographic, physical and mental health assessments in the Adolescent Brain and Cognitive Development Study: Rationale and description
Dev Cogn Neurosci
Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data
J Am Acad Child Adolesc Psychiatry
The Computerized Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS): Development and administration guidelines
J Am Acad Child Adolesc Psychiatry
Development of three web-based computerized versions of the Kiddie Schedule for Affective Disorders and Schizophrenia Child Psychiatric Diagnostic Interview: Preliminary validity data
J Am Acad Child Adolesc Psychiatry
Latent class analysis of the Child Behavior Checklist Obsessive-Compulsive Scale
Compr Psychiatry
A quick and reliable screening measure for OCD in youth: Reliability and validity of the obsessive compulsive scale of the Child Behavior Checklist
Compr Psychiatry
Reliability and validity of the Child Behavior Checklist Obsessive-Compulsive Scale
J Anxiety Disord
The Obsessive-Compulsive Symptom (OCS) scale of the Child Behavior Checklist: A comparison between Swedish children with obsessive-compulsive disorder from a specialized unit, regular outpatients and a school sample
J Anxiety Disord
The Adolescent Brain Cognitive Development (ABCD) Study: Imaging acquisition across 21 sites
Dev Cogn Neurosci
Cortical surface–based analysis. I. Segmentation and surface reconstruction
Neuroimage
Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain
Neuron
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
Neuroimage
Obsessive-compulsive symptom dimensions in the general population: Results from an epidemiological study in six European countries
J Affect Disord
Cognitive inflexibility in obsessive-compulsive disorder
Neuroscience
Toward a neurobiology of obsessive-compulsive disorder
Neuron
Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited
Neurosci Biobehav Rev
Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder
Biol Psychiatry
White matter abnormalities in pediatric obsessive-compulsive disorder
Psychiatry Res
Correlations and anticorrelations in resting-state functional connectivity MRI: A quantitative comparison of preprocessing strategies
Neuroimage
Obsessions and compulsions in the community: Prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions
Am J Psychiatry
Obsessive-compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: A population-based study of Brazilian school children
Eur Child Adolesc Psychiatry
A prospective study of paediatric obsessive-compulsive symptomatology in a Spanish community sample
Child Psychiatry Hum Dev
The neuropsychological profile of a subclinical obsessive-compulsive sample
J Int Neuropsychol Soc
Poor cognitive flexibility, and the experience thereof, in a subclinical sample of female students with obsessive-compulsive symptoms
Scand J Psychol
Declarative and procedural learning in individuals with subclinical obsessive-compulsive symptoms
J Clin Exp Neuropsychol
A phenotypic structure and neural correlates of compulsive behaviors in adolescents
PLoS One
Neuroimaging and neuropsychological findings in pediatric obsessive-compulsive disorder: A review and developmental considerations
Neuropsychiatry
Developmental neuroimaging in pediatric obsessive-compulsive disorder
Current Behav Neurosci Rep
Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: A review of literature and preliminary meta-analysis
J Neural Transm (Vienna)
Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder
J Child Psychol Psychiatry
Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder
Neuropsychopharmacology
Distinct subcortical volume alterations in pediatric and adult OCD: A worldwide meta- and mega-analysis
Am J Psychiatry
Cortical abnormalities associated with pediatric and adult obsessive-compulsive disorder: Findings from the ENIGMA Obsessive-Compulsive Disorder Working Group
Am J Psychiatry
The Obsessive Compulsive scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: A receiver operating characteristic curve analysis
J Child Psychol Psychiatry
Cited by (16)
Hyperconnecitivity between dorsal attention and frontoparietal networks predicts treatment response in obsessive-compulsive disorder
2024, Psychiatry Research - NeuroimagingChanges in Brain Network Connections After Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder in Adolescents and Adults
2024, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingHunting the Brain Basis of a Mind Under Siege
2022, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingSymptom-Based Profiling and Multimodal Neuroimaging of a Large Preteenage Population Identifies Distinct Obsessive-Compulsive Disorder–like Subtypes With Neurocognitive Differences
2022, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingCitation Excerpt :The precuneus, which projects to prefrontal cortex densely and is associated with thought–action fusion (74), has been implicated as a key structure in OCD (75). It should be noted that thalamic volume reduction was found in G1 [although this did not pass FDR correction, which is consistent with Pagliaccio et al. (63), who showed negative correlation between thalamic volume and symptom scores]. These results are inconsistent with the increased thalamic volume (12,76) found for OCD, possibly owing to different data collection, different analysis methods, and potential confounding factors such as age and other demographic features.
Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms
2022, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingCitation Excerpt :In addition to consistency across different analytic methods, genuine group differences should be replicated in independent studies and by independent investigators. Our study shows a high degree of consistency with the pattern of OCS dysconnectivity reported in a recent study in preadolescent children from the Adolescent Brain and Cognitive Development study (7). The consistency between the studies is remarkable given that we examined a nonoverlapping age group of adolescents (11–21 years, mean age = 15.9), and we used self-report OCS in contrast to Adolescent Brain and Cognitive Development OCS phenotyping that relies exclusively on parent report.
Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children
2022, Biological Psychiatry Global Open Science