Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
ReviewSpeaking-Induced Suppression of the Auditory Cortex in Humans and Its Relevance to Schizophrenia
Section snippets
Quantifying SIS in Human Participants
There is substantial evidence from single-unit recording studies that the activity of (some) auditory cortex neurons are suppressed during the production of willed vocalizations in nonhuman primates (8) and other nonhuman animals 9, 10. Similar results have also been reported in human participants undergoing neurosurgery: single-unit electrodes placed in the exposed temporal cortex in humans revealed suppressed neuronal firing rates in the auditory cortex when participants produced willed
SIS of the Auditory Cortex Is Reduced in People With Schizophrenia
Schizophrenia is a severe mental illness with a lifetime prevalence of slightly less than 1% (76). The neurophysiological basis of the disorder remains poorly understood, and as a consequence, the available treatment options for schizophrenia are highly imperfect 77, 78, 79. The key to establishing the neurophysiological basis of schizophrenia lies in understanding the mechanisms that give rise to its distinctive symptoms.
Schizophrenia is a psychotic disorder, which is to say it is
The (Hypothesized) Relationship Between SIS and the First-Rank Symptoms of Schizophrenia
Arguably the greatest strength of the corollary-discharge theory of schizophrenia 85, 86 lies in its ability to provide a direct and plausible account of the first-rank symptoms. This is particularly true of delusions of control, which have long been conceptualized as reflecting the misattribution of self-generated movements to external sources (102). In light of this, it is somewhat surprising that so few studies have explored the association between N1-suppression deficits and the first-rank
Suppression of the Auditory Cortex in Response to Inner Speech: An Explanation for Auditory-Verbal Hallucinations?
In a similar way to how delusions of control have been argued to reflect the misperception of self-generated movements as externally generated movements, some types of auditory-verbal hallucinations have been argued to reflect the misperception of inner speech as being external speech 85, 86, 113, 114, 115. One particularly direct example is the phenomenon of audible thoughts, also known as thought echo. Audible thoughts are a type of auditory-verbal hallucination in which the patient hears his
Acknowledgments and Disclosures
This research was supported by a Discovery Project from the Australian Research Council (Grant No. DP170103094). TJW is supported by a Career Development Fellowship from the National Health and Medical Research Council of Australia (Grant No. APP1090507).
The author reports no biomedical financial interests or potential conflicts of interest.
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2023, NeuroImage: ClinicalCitation Excerpt :In a recent review, Whitford (2019) examined 19 experiments assessing sensory self-suppression in people with psychosis versus controls. Of the 14 studies identified by Whitford (2019): 2 did not look at relationships with specific clinical symptoms, 8 found no evidence of a relationship with clinical symptoms, 1 found evidence on a secondary measure, and 3 found positive evidence of a relationship with different clinical symptoms. Work in this area has historically been challenged by low sample sizes and variation between symptom measures, and variance within the measures themselves.