Antiviral properties and interaction of novel chalcone derivatives containing a purine and benzenesulfonamide moiety
Graphical abstract
Novel chalcone derivatives containing a purine and benzenesulfonamide moiety were synthesized. Compound d2 exhibited excellent antiviral activity against TMV and CMV. The interaction mode of the compound d2 with TMV-CP was performed through molecular docking, fluorescence titration (FT) and microscale thermophoresis (MST) techniques.
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Acknowledgments
This study was supported by the National Natural Science Foundation of China (Nos. 21562013 and 21362004), Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China (No. 20154004), the Provincial University Cooperation Plan of Guizhou Province in China (No. 20147001) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan.
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