Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist–serotonin reuptake transporter inhibitor

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Abstract

Cyclopentylamine 4 was identified as a potent dual NK1R antagonist–SERT inhibitor. This compound demonstrated significant oral activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists–SERT inhibitors may be useful in treating depression disorders.

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