Novel Aza-resveratrol analogs: Synthesis, characterization and anticancer activity against breast cancer cell lines
Graphical abstract
Novel Aza-resveratrol analogs were synthesized, structurally characterized and evaluated for cytotoxic activity against MDA-MB-231 and T47D breast cancer cell lines, which exhibited superior inhibitory activity than parent resveratrol compound. The binding characteristics of the compounds with estrogen receptor-α (ER-α) were rationalized by molecular docking studies which indicated that these new Aza-resveratrol analogs favor additional hydrogen binding interactions than resveratrol and hence achieve more stability and tight binding in the protein cavity.
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