Cytotoxic and PPARs transcriptional activities of sterols from the Vietnamese soft coral Lobophytum laevigatum
Graphical abstract
A new unusual sterol, named lobophytosterol (1), and five known metabolites (2–6) were isolated from the methanol extract of the soft coral Lobophytum laevigatum. Compounds 1–3 showed cytotoxic activity against selected human cancer cell lines. Treatment of these cells with compound 1 resulted in an induction of apoptosis evident by chromatin condensation in treated cells. Besides, compounds 2, 4, and 6 significantly upregulated PPARs transcriptional activity dose-dependently in Hep-G2 cells.
Section snippets
Acknowledgments
This work was financially supported by Vietnam’s National Foundation for Science and Technology Development (NAFOSTED, No. 104.01.30.09) and the Priority Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors would like to thank Dr. Do Cong Thung, Institute of Marine Resources and Environment, VAST for the sample identification.
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