Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity
Graphical abstract
The synthesis and Src kinase inhibitory activity of two classes of 1,4-disubstituted 1,2,3-triazoles are reported.
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Acknowledgments
We thank University Grants Commission (SAP, DRS), Birla Institute of Technology & Science, Pilani, India National Science Foundation, Grant # CHE 0748555, and the American Cancer Society Grant # RSG-07-290-01-CDD for the financial support.
References and notes (24)
- et al.
Bioorg. Med. Chem.
(2004) - et al.
Bioorg. Med. Chem. Lett.
(2007) - et al.
Bioorg. Med. Chem. Lett.
(2003) - et al.
Bioorg. Med. Chem. Lett.
(2005) - et al.
Mol. Cancer Ther.
(2008) - et al.
Mol. Cell
(1999)et al.Struct. Fold Des.
(1999) - et al.
ChemMedChem
(2007) - et al.
J. Med. Chem.
(1986) - et al.
Farmaco
(1992)et al.Antimicrob. Agents Chemother.
(1998) - et al.
J. Med. Chem.
(2000)
New J. Chem.
Org. Biomol. Chem.
Multicomponent Reactions
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