Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Graphical abstract
A novel series of potent active-site inhibitors for HCV NS5B polymerase was identified, and the corresponding X-ray structural study was described.
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Acknowledgments
We thank Vesna Stojiljkovic for compound purifications; Vicky Lai, Weidong Zhong, Shannon Dempsey, Heli Walker, and Daniel Bellows for performing biological assays.
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