Original ArticleRisperidone and Cognitive Function in Children With Disruptive Behavior Disorders
Section snippets
Methods and Materials
Detailed information regarding patient populations, study designs, procedures, and data analysis has been previously published for two double-blind, placebo-controlled, 6-week studies (Aman et al 2002, Snyder et al 2002), their 1-year, open-label extensions (Findling et al 2004, Turgay et al 2002), and a separate 1-year, open-label study (Croonenberghs et al. 2005). Institutional review boards at each center approved the respective studies. Similar populations, measures, medications, and data
Results
A total of 228 subjects participated in the two short-term studies, and 688 subjects participated in the three one-year studies. Baseline characteristics are presented in Table 2. Eighty-three percent of risperidone-treated and 68% of placebo-treated patients completed the 6-week, double-blind studies. The most common reason for withdrawal among placebo patients was insufficient response (28%, Table 3). Few risperidone-treated patients withdrew owing to insufficient response (6%) or adverse
Discussion
As previously reported for individual studies, combined analysis indicated that risperidone treatment was associated with improvements on the NCBRF Conduct Problem subscale in both short- and long-term studies. The present analysis focused on an examination of cognitive function in a large number of children. No declines in measures of attention or verbal learning were noted with either risperidone or placebo during short-term (six weeks) treatment. Importantly, combined data from three
References (22)
- et al.
The Nisonger CBRF: a child behavior rating form for children with developmental disabilities
Res Dev Disabil
(1996) - et al.
Oppositional defiant disorder and conduct disorder: a review of the past 10 years, part II
J Am Acad Child Adolesc Psychiatry
(2002) - et al.
Risperidone in children with disruptive behavior disorders and subaverage intelligence: a one-year, open-label study of 504 patients
J Am Acad Child Adolesc Psychiatry
(2005) - et al.
Effects of risperidone on conduct and disruptive behavior disorders in children with subaverage IQs
J Am Acad Child Adolesc Psychiatry
(2002) - et al.
Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence
Am J Psychiatry
(2002) - et al.
The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects
Am J Ment Defic
(1985) Diagnostic and Statistical Manual of Mental Disorders
(2000)- et al.
The evolution of ADHD: a disorder of communication?
Q Rev Biol
(2000) - et al.
CVLT-C: California Verbal Learning Test–Children’s Version
(1994) - et al.
Peabody Picture Vocabulary Test–Third Edition
(1997)
Long-term open-label study of risperidone in children with severe disruptive behaviors and subaverage intelligence
Am J Psychiatry
Cited by (20)
The prevalence of psychiatric disorders among 3–4 year olds in an urban sample in Bangladesh
2020, Asian Journal of PsychiatryCitation Excerpt :The developing capacity from birth to six is crucial to experience, regulate, and express emotions; to form close relationships; and to explore the environment and learn — all in the context of family, community, and cultural expectations for young children. The many emotional and behavioral problems start during preschool age and they continue to prevail in further developmental stages (Pandina et al., 2007). Therefore, it is now recognized that very young children can experience significant emotional and behavioral problems similar to the latter period.
Discovery of previously undetected intellectual disability by psychological assessment: A study of consecutively referred child and adolescent psychiatric inpatients
2014, Research in Developmental DisabilitiesScaling methods to measure psychopathology in persons with intellectual disabilities
2012, Research in Developmental DisabilitiesCitation Excerpt :Snyder et al. (2002) conducted a similar study with 110 children who were 5–12 years old again using risperidone. The same methodology in Snyder et al. (2002) has been used in multiple other studies (Aman, Binder, & Turgay, 2004; Aman et al., 2009; Biederman et al., 2006; Croonenberghs, Fegert, Findling, De Smedt, & Van Dongen, 2005; Findling et al., 2003, 2006, 2007; Findling, Aman, Eerdekens, Derivan, & Lyons, 2004; LeBlanc et al., 2005; Pandina et al., 2007; Reyes, Buitelaar, Toren, Augustyns, and Eerdekens, 2006; Reyes, Croonenberghs, Augustyns, & Eerdekens, 2006; Shea et al., 2004). We chose to include the NCBRF given the emphasis by the authors on measuring emotional problems.
Prevalence of conduct disorder among elementary students in Tehran city
2011, Procedia - Social and Behavioral SciencesEffects of risperidone on cognitive-motor performance and motor movements in chronically medicated children
2009, Research in Developmental DisabilitiesUsing a Delphi Process to Update the Nisonger Child Behavior Rating Form
2022, American Journal on Intellectual and Developmental Disabilities