Review
Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress

https://doi.org/10.1016/j.biopha.2021.111534Get rights and content
Under a Creative Commons license
open access

Highlights

  • ROS accumulation induced-oxidative stress exemplifies the crucial part of PM-induced damage.

  • Many natural compounds which present high antioxidant capacity could reduce ROS production.

  • Natural antioxidants combinded with biological materials will be the hot topic.

Abstract

Particulate matter (PM) is a common indirect indicator of air pollution and threatens public health upon prolonged exposure, leading to oxidative stress, increasing the risk of develop respiratory and cardiovascular, as well as several autoimmune diseases and cancer. Nowadays, as a first line defense against PM, skin health attracted much attention. Our review summarized the skin damage mechanism induced by PM, including damage skin barrier directly, reactive oxygen species (ROS) accumulation, autophagy, and two canonical signaling pathways. Furthermore, ROS and oxidative stress have been considered pathogenesis centers, with essential skin damage roles. Extracts from plants and natural compounds which present high antioxidant capacity could be used to treat or protect against air pollution-related skin damage. We conclude the extracts reported in recent studies with protective effects on PM-mediated skin damage. Besides, the mechanism of extracts' positive effects has been revealed partially.

Keywords

PM
Skin
Antioxidants
Extracts

Cited by (0)