ReviewHypoxia-mediated cancer stem cell resistance and targeted therapy
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Graphical abstract
Abbreviations
CSC
cancer stem cell
HIF
hypoxia-inducible factor
HRE
hypoxic response elements
ADT
androgen deprivation therapy
PTX
paclitaxel
bHLH
basic-helix-loop-helix
PAS
PER-ARNT-SIM
ODD
oxygen-dependent degradation
TAD
transactivation domains
N-TAD
NH2-terminal
C-TAD
COOH-terminal
pVHL
von Hippel-Lindau protein
PDAC
pancreatic ductal adenocarcinoma
RP2D
recommended phase II dose
Keywords
Cancer stem cells (CSCs)
Hypoxia inducible factors (HIFs)
Tumor resistance
HIF inhibitors
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© 2020 The Authors. Published by Elsevier Masson SAS.