Ameliorative effect of Homalium zeylanicum against carbon tetrachloride-induced oxidative stress and liver injury in rats
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Graphical abstract
Abbreviations
ROS
reactive oxygen species
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
APG
angiosperm phylogeny group
RT
retention time
m/z
mass to charge ratio
ORAC
oxygen radical absorbance capacity
CAP-e
cell-based antioxidant protection in erythrocytes
SGOT
serum glutamate oxaloacetate transaminase
SGPT
serum glutamate pyruvate transaminase
ALP
alkaline phosphatase
TB
total bilirubin
TP
total protein
TBARS
thiobarbiturc acid reactive species
AAPH
2,2′azobis-2-amidinopropane hydrochloride
DCF-DA
dichlorofluorescein diacetate
HZEB
ethyl acetate fractions of bark
HZEL
ethyl acetate fractions of leaf
CPCSEA
committee for the purpose of control and supervision of experiments on animals
IAEC
institutional animal ethical committee
LD50
lethal dose
OECD
organisation for economic co-operation and development
AAPH
22´-azobis-2-amidinopropane hydrochloride
SOD
superoxide dismutase
CAT
catalase
GSH
reduced glutathione
IC50
inhibitory concentration
PBS
phosphate buffer saline
FI
fluorescence intensity
AUC
area under curve
MDA
malondoaldehye
ABB
albumin-bound-bilirubin
UGT1A1
UDP-glucuronosyltransferase
LFT
liver function test
PUFA
polyunsaturated fatty acids
Chemical compounds studied in this article
CID: silymarn (CID: 1548994)
22′-azobis-2-amidinopropane hydrochloride (CID: 84924)
2′7′-dichlorofluorescein diacetate (CID:77718)
Keywords
Homalium zeylanicum
ORAC
CAP-e
Antioxidant
serum marker
Hepatic marker
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© 2018 The Authors. Published by Elsevier Masson SAS.