Short communicationConsolidation of an aversive taste memory requires two rounds of transcriptional and epigenetic regulation in the insular cortex
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Acknowledgements
This research was supported by PAPIITIN215816.
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Cited by (5)
Epigenetic mechanisms regulate cue memory underlying discriminative behavior
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :A 2014 study by Nuñez-Jaramillo and colleagues (Núñez-Jaramillo et al., 2014) found that infusing the general class I HDAC inhibitor, sodium butyrate (NaB), in the IC during CTA strengthened the associative memory between the taste cue and malaise, which was revealed behaviorally as delayed extinction of the taste aversion. The same effect of HDAC inhibition on CTA memory was also reported by (Rodríguez-Blanco et al., 2019) with post-training IC injections of the HDAC1/3-selective inhibitor MS-275 (“entinostat”). In this study, the authors determined that at least two rounds of transcription – one immediately, and one 7 h after CTA acquisition – were needed to strengthen CTA memory consolidation for a specific flavor.
Artificial taste avoidance memory induced by coactivation of NMDA and β-adrenergic receptors in the amygdala
2019, Behavioural Brain ResearchCitation Excerpt :All these processes culminate in the increase in protein synthesis required for neuronal remodeling within the neural networks necessary to acquire and consolidate taste avoidance memories [37]. In this regard, it has been proposed that a single molecular event triggered during acquisition may not be sufficient to maintain long-term memory; and the persistence of memory requires rounds of consolidation-like processes during different time windows [38–41]. Therefore, we suggest that emulation of US amygdalar events is necessary to initiate the molecular pathways involved in modifications of the amygdala-insular network and the coactivation of NMDA and β-adrenergic receptors during the post-learning period facilitates the taste avoidance memory consolidation through protein synthesis-dependent mechanisms.
Trichostatin a inhibits phenotypic transition and induces apoptosis of the TAF-treated normal colonic epithelial cells through regulation of TGF-β pathway
2019, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Post-translational modifications of histones play an important role in transcriptional regulation (Nakamura et al., 2018; Hatakeyama et al., 2018). Acetylation and deacetylation of histone tails, respectively mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC), regulate gene activation and repression (Kelly et al., 2018; Rodríguez-Blanco et al., 2019). Cumulative evidence suggests aberrant HAT and HDAC activities in several cancer cells (Yu et al., 2018; Shanmugam et al., 2017).