Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1803, Issue 1, January 2010, Pages 55-71
ReviewThe tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
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Abbreviations
TIMP
tissue inhibitor of metalloproteinases
MMP
matrix metalloproteinase
ADAM
a disintegrin and metalloprotease
ADAMTS
ADAM with thrombospondin motifs
ECM
extracellular matrix
TACE
tumor necrosis factor α converting enzyme
MAPK
mitogen activated protein kinase
PI3-K
phosphoinositide 3-kinase
FAK
focal adhesion kinase
ERK
extracellular signal-regulated kinases
HGF
hepatocyte growth factor
IL-1
interleukin 1
TNFα
tumor necrosis factor α
TGF
transforming growth factor
VEGF
vascular endothelial cell growth factor
FGF
fibroblast growth factor
LDL
low-density lipoprotein
LRP
LDL receptor related protein
RECK
the reversion-inducing cysteine-rich protein with Kazal motif
LPS
lipopolysaccharide
SFD
Sorsby fundus dystrophy
AMD
age-related macular degeneration
EFEMP
EGF-containing fibulin-like extracellular matrix protein
Keywords
Matrix metalloproteinase
Extracellular matrix
Evolution
Multifunctional protein
Cell growth
Sorsby fundus dystrophy
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