Original articleGeneral thoracicDetailed Analysis of Prognostic Factors in Primary Esophageal Small Cell Carcinoma
Section snippets
Patients
The study was approved by the Research Ethics Committees of Sun Yat-Sen University, Peking Union Cancer Hospital, and Shantou Cancer Hospital. Clinical information for SCCE patients was retrieved from the original clinical databases of the three cancer centers from 1998 to 2012. The diagnosis of SCCE was histologically confirmed by the pathology department before enrollment. The patients were followed up until January 2013. The 2002 AJCC staging system for esophageal cancer was applied to all
Patient and Clinical Characteristics
In total, 211 patients were identified from the three institutions. The median follow-up time was 15.7 months (range, 1–127.4 months). The detailed patient characteristics are listed in Table 1. There were 14.7% of tumors located in the cervical/upper segment of the esophagus, 58.8% in the middle segment, and 26.5% in the lower segment. According to the 2002 AJCC staging system, the study enrolled 17 (8.1%) stage I patients, 43 (20.4%) stage IIA patients, 21 (10.0%) stage IIB patients, 70
Comment
In this study, the long-term follow-up made it possible to find potential predictors for survival. Given that more than half of the patients underwent surgical treatment or chemotherapy and more than one quarter of them underwent radiotherapy in our study, the comparison between different treatment approaches was achievable.
The rarity of SCCE makes it difficult to conduct a randomized clinical trial. Thus, clinical decision making for patients with SCCE mainly relies on retrospective studies
References (38)
- et al.
Small-cell carcinoma of the esophagus and gastroesophageal junction: review of the Memorial Sloan-Kettering experience
Ann Oncol
(2008) - et al.
Primary small cell carcinoma of the esophagus
J Thorac Oncol
(2008) - et al.
Management of small cell carcinoma of esophagus in china
J Gastrointest Surg
(2013) - et al.
Small cell carcinoma of the esophagus: the Tata Memorial Hospital experience
Ann Thorac Surg
(2002) - et al.
Small cell carcinoma of the esophagus: a report of 16 cases from a single institution and literature review
Ann Thorac Surg
(2011) - et al.
Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma
Radiother Oncol
(2013) - et al.
Treatment and prognosis of limited disease primary small cell carcinoma of esophagus
Dis Esophagus
(2011) - et al.
Surgical treatment for limited-stage primary small cell cancer of the esophagus
Ann Thorac Surg
(2013) - et al.
Complete response of esophageal small cell carcinoma amrubicin treatment
J Infect Chemother
(2013) Oat-cell carcinoma of the oesophagus
J Pathol Bacteriol
(1952)
Small cell carcinoma of the esophagus: a SEER database analysis
Ann Surg Oncol
Tumor spread and outcome of treatment in primary esophageal small cell carcinoma
J Surg Oncol
Esophageal small cell carcinomas: clinicopathologic parameters, p53 overexpression, proliferation marker, and their impact on pathogenesis
Arch Pathol Lab Med
Small cell carcinoma of the esophagus: analysis of 14 cases and literature review
Hepatogastroenterology
Non-operative management of small cell carcinoma of esophagus
Dis Esophagus
Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases
BMC Cancer
Small cell carcinoma of the esophagus: a multicentre rare cancer network study
Dis Esophagus
Diagnosis, staging, and prognostic factors of small cell lung cancer
Curr Opin Oncol
The American Joint Committee on Cancer: updating the strategies in cancer staging
Bull Am Coll Surg
Cited by (0)
- ∗
Drs Wei-Wei Chen and Feng Wang contributed equally to this study.