REVIEW
Biomimetic nanoparticles for inflammation targeting

https://doi.org/10.1016/j.apsb.2017.12.002Get rights and content
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Abstract

There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels, and molecular mediators directed against harmful stimuli, is closely associated with many human diseases. As a result, biomimetic nanoparticles mimicking immune cells can help achieve molecular imaging and precise drug delivery to these inflammatory sites. This review is focused on inflammation-targeting biomimetic nanoparticles and will provide an in-depth look at the design of these nanoparticles to maximize their benefits for disease diagnosis and treatment.

Graphical abstract

This review talks about basic strategies of inflammation-targeting biomimetic nanoparticles, which includes i) synthetic nanoparticles modified with targeting ligands that mimic cell surface proteins; ii) cell membrane-coated nanoparticles; iii) liposomes engineered with cell membrane proteins.

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Abbreviations

apoE–/– mice
Apolipoprotein e knockout mice
CAM
cellular adhesion molecule
CCL5
chemokine (C-C motif) ligand 5
CD40L
cluster of differentiation 40 ligand
CTC
circulating tumor cell
CTL
cytotoxic T cell or CD8+ T cell
CXCL4
chemokine (C-X-C motif) ligand 4
CXCR1
chemokine (C-X-C motif) receptor 1
Cy7
cyanine 7
DC
dendritic cell
DSPE-PEG
distearoyl Phosphoethanolamine-poly(ethylene glycol)
GPIbα
glycoprotein Ibα
GPIV
glycoprotein IV
GPIX
glycoprotein IX
GPV
glycoprotein V
GPVI
glycoprotein VI
HUVEC
umbilical cord vascular endothelial cell
IBD
inflammatory bowel disease
ICAM-1
intercellular cellular adhesion molecule-1
IgG
immunoglobulin G
IL
interleukin
LFA-1
lymphocyte function associated antigen-1
LLV
leukocyte-like vector
LPS
lipopolysaccharide
Mac-1
macrophage adhesion molecule-1
MHC
major histocompatibility complex
MRI
magnetic resonance imaging
NM-NP
neutrophil membrane-coated nanoparticle
PECAM-1
platelet-endothelial cellular adhesion molecule-1
PLA-PEG
poly(lactic acid)-poly(ethylene glycol)
PLGA
poly(lactic-co-glycolic acid)
PNP
platelet membrane-cloaked nanoparticle
PSGL-1
P-selectin glycoprotein ligand-1
RA
rheumatoid arthritis
RBC
red blood cell
SLeX
sialyl lewis X
SPIO
super paramagnetic iron oxide
TGF-β
transforming growth factor β
Th cell
T-helper cell or CD4+ T cell
TNF-α
tumor necrosis factor-α
VCAM-1
vascular cellular adhesion molecule-1
VLA-4
very late antigen-4
VWF
Von Willebrand factor

KEY WORDS

Biomimetic nanoparticles
Inflammation targeting
Immune cells
Targeting ligands
Cell membrane
Cell membrane proteins
Molecular imaging

Cited by (0)

Peer review under responsibility of Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.

†

These authors made equal contributions to this work.

© 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.