Original articlePostural Response Latencies Are Related to Balance Control During Standing and Walking in Patients With Multiple Sclerosis
Section snippets
Participants
A total of 40 subjects with MS (mean age, 45.6±11.7y; height, 166.4±18.4cm; weight, 78.1±19.9kg) and 20 healthy controls subjects (mean age, 41.8±10.7y; height, 167.9±15.5cm; weight, 78.7±17.7kg) participated in the study.
Patients with MS (n=40), recruited through the Oregon Health Science University's MS clinic, and healthy control subjects (n=20), recruited through the community, provided informed consent. The research protocol was approved by the university's institutional review board.
Relation between postural response latency and COP sway variables
Within the individual normal walking velocity MS and slow walking velocity MS groups, there were no significant correlations between postural response latency and COP displacement root mean square, range, mean velocity, or total sway area. Across all subjects with MS, postural response latency was significantly correlated with COP displacement root mean square (r=.363, P=.025), range (r=.37, P=.022), mean velocity (ρ=.349, P=.032), and total sway area (r=.353, P=.03). Within the healthy control
Discussion
The purpose of this study was to examine the relation between postural response latencies and balance dysfunction during standing and walking in patients with MS. Postural response latency was measured in subjects with MS who had no clinical gait deficits (normal walking velocity MS group), in subjects with MS with slow gait velocity (slow walking velocity MS group), and in similar-aged healthy control subjects. The automatic postural responses of the healthy controls to these moderate
Conclusions
Persons with MS have delayed responses to postural perturbation, and these responses contribute to disturbances in postural control during both standing and walking. However, it is not clear how other factors (eg, loss of strength, spasticity, fatigue) impact gait and postural control. It will be necessary to examine postural response latency and gait and balance variables across a larger and broader spectrum of disability levels in subjects with MS to better understand whether postural
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Impact of pathological conditions on postural reflex latency and adaptability following unpredictable perturbations: A systematic review and meta-analysis
2022, Gait and PostureCitation Excerpt :The 53 eligible articles had sample sizes ranging from 9 to 170 participants. Experimental studies compared postural reflexes in people with and without multiple sclerosis (n = 7) [17–23], Parkinson’s disease (n = 10) [24–33], history of stroke (n = 10) [34–43], cerebellar dysfunction (n = 4) [44–47], diabetes (n = 2) [5,48], HIV (n = 3) [49–51], iSCI (n = 2) [52,53] and pain (n = 7) [15,54–59]. Seven intervention studies examined adaptation of postural reflexes to exercise interventions in people with Parkinson’s disease (n = 3) [31,32,60], stroke (n = 3) [61–63] and cerebellar dysfunction (n = 1) [47].
The relationship between plantar sensation and muscle onset during automatic postural responses in people with multiple sclerosis and healthy controls
2021, Multiple Sclerosis and Related DisordersCitation Excerpt :The ability to elicit a quick and effective automatic postural response (APR) after a sudden balance challenge is vital to guard against a fall (Mansfield et al., 2013). Compared to healthy controls, PwMS demonstrate impaired reactive balance characterized by delayed muscle onset (Aruin et al., 2015; Gera et al., 2016; Huisinga et al., 2014; Peterson et al., 2016; Tajali et al., 2018) and more significant center of mass displacement (Aruin et al., 2015; Jacobs and Kasser, 2012) after a balance challenge. Indeed, a delayed or otherwise compromised APR may increase the likelihood of falls in PwMS, neurotypical older adults, and stroke survivors (Batcir et al., 2020; Mansfield et al., 2013; Peterson et al., 2016).
Middle-age people with multiple sclerosis demonstrate similar mobility characteristics to neurotypical older adults
2021, Multiple Sclerosis and Related DisordersCitation Excerpt :Moreover, condition 3 of the mCTSIB (eyes open, compliant surface) produced several variables that met the AUC threshold, however, only sway area (m2/s4) was withheld in the regression model. These results further confirm the reduced somatosensory feedback observed in PwMS and provide a commonly measured variable capable of discriminating between groups [43-45]. Taken together, while gait characteristics were significantly different, turning, and moreover balance measures were capable of discriminating between groups.
Non-invasive brain stimulation to assess neurophysiologic underpinnings of lower limb motor impairment in multiple sclerosis
2021, Journal of Neuroscience Methods
Supported by the National Multiple Sclerosis Society (grant no. MB 0011) and the National Institutes of Health (grant no. AG006457).
No commercial party having a direct financial interest in the results of the research supporting this article has conferred or will confer a benefit on the authors or on any organization with which the authors are associated.