Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use

doi:10.1016/j.apjtb.2015.09.002

Asian Pacific Journal of Tropical Biomedicine

Volume 5, Issue 12, December 2015, Pages 982-986

https://doi.org/10.1016/j.apjtb.2015.09.002 Get rights and content

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Abstract

Objective

To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria.

Methods

A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi.

Results

The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC₅₀ 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2 000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P < 0.001), suggesting significant prophylactic activity.

Conclusions

The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.

Keywords

Polyherbal remedy

Plasmodium

Malaria prophylaxis

Antiplasmodial activity

Cited by (0)

: Foundation Project: Aquarius Group of Companies, Singapore and ETC CAPTURED Programme, the Netherlands (Grant No. DGIS/D).

: Peer review under responsibility of Hainan Medical University.