Raltegravir-induced drug reaction with eosinophilia and systemic symptoms syndrome in a child

doi:10.1016/j.anai.2016.09.433

Annals of Allergy, Asthma & Immunology

Volume 117, Issue 6, December 2016, Pages 719-721

https://doi.org/10.1016/j.anai.2016.09.433 Get rights and content

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Acknowledgments

We thank Dr Kenneth Boyer for his input. Dr Logan acknowledges funding from the National Institutes of Health under grant K08AI112506.

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The DRESS syndrome: a literature review
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Raltegravir-induced DRESS syndrome
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Raltegravir-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: implications for clinical practice and patient safety
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Yee BE, Nguyen NH, Lee D. Extensive pulmonary involvement with raltegravir-induced DRESS syndrome in a postpartum woman...

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Cited by (4)

Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: A systematic review of the literature
2020, Journal of the American Academy of Dermatology
Citation Excerpt :
The initial literature search yielded 678 results after duplicate articles were removed. A total of 82 studies with 148 patients (82 boys [55.4%]) were included (Fig 1).2,6-20,21-40,41-60,61-75,76-86 Of the included studies, 72 (87.8%) were isolated case reports, with 1 prospective study and 9 retrospective studies.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that can have fatal complications. Although substantial data exist regarding DRESS in adults, to our knowledge, a systematic review of available literature has not been performed in children.
To review available data on DRESS in the pediatric population.
A systematic literature review was performed for pediatric (aged <18 years) patients with DRESS.
We included 82 articles with 148 patients; of these, 97.9% experienced a skin rash, and the liver was the second most common organ involved (84.5%). Among 143 patients for which a treatment regimen was reported, 85.3% were treated with systemic steroids. Intravenous immunoglobulin alone failed to improve symptoms in 5 patients who were initially misdiagnosed, whereas those treated with intravenous immunoglobulin and steroids (2.7%) showed rapid clinical improvement. The mortality rate was low (3.0%). Complications included multiorgan failure and acute respiratory distress syndrome.
Limitations included limited availability of data for statistical analysis.
Pediatric DRESS commonly involves the liver. With treatment, the prognosis is commonly good, but serious complications may occur. Corticosteroids, possibly in conjunction with intravenous immunoglobulin in severe cases, may serve as an effective, valuable treatment of pediatric DRESS.
Raltegravir-associated Drug-Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient without Characteristic Human Leukocyte Antigen B∗57:01 or B∗53:01 alleles
2021, Journal of the Pediatric Infectious Diseases Society
Rate of DRESS Syndrome with Raltegravir and Role of the HLA-B*53:01 Allele
2020, Journal of Acquired Immune Deficiency Syndromes
Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review
2019, Pediatric Dermatology

: Disclosures: Authors have nothing to disclose.

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Annals of Allergy, Asthma & Immunology

LetterRaltegravir-induced drug reaction with eosinophilia and systemic symptoms syndrome in a child

Section snippets

Acknowledgments

First page preview

The DRESS syndrome: a literature review

Am J Med

Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antidrug immune responses

Allergol Int

Raltegravir-induced DRESS syndrome

Scand J Infect Dis

Raltegravir-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: implications for clinical practice and patient safety

Int J STD AIDS

Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: A systematic review of the literature

Raltegravir-associated Drug-Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient without Characteristic Human Leukocyte Antigen B∗57:01 or B∗53:01 alleles

Rate of DRESS Syndrome with Raltegravir and Role of the HLA-B*53:01 Allele

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Letter
Raltegravir-induced drug reaction with eosinophilia and systemic symptoms syndrome in a child