AJM onlineClinical research studyClinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome
Section snippets
Methods
Institutional Review Board approval was obtained at the University of Virginia prior to initiating the study. One hundred forty patients with a diagnosis of gastric antral vascular ectasia examined between 1995 and 2013 were identified through clinic records and an institutional Clinical Data Repository database based on International Classification of Diseases, Ninth Revision coding. Five patients were excluded for incomplete records. The remaining 135 case patients were matched in a 1:1 ratio
Patient Population
A total of 140 patients were identified with endoscopic findings diagnostic of gastric antral vascular ectasia. Five of these patients were excluded for incomplete records. Thus, a total of 135 patients with a diagnosis of gastric antral vascular ectasia were matched to 135 patients without gastric antral vascular ectasia. As in past studies, our institutional practice has been to rely on the endoscopic appearance to diagnose gastric antral vascular ectasia, although 10 of the cases had a
Discussion
Gastric antral vascular ectasia is a well-described gastric disorder that can lead to acute and chronic gastrointestinal bleeding.5, 22 We present a modern cohort of 135 gastric antral vascular ectasia patients matched with 135 patients without gastric antral vascular ectasia. To our knowledge, this is the largest cohort of patients with gastric antral vascular ectasia reported in the literature to date and the first clinical characterization since 1992.14 Our univariate analysis confirms the
References (41)
- et al.
Gastritis with veno-capillary ectasia as a source of massive gastric hemorrhage
Gastroenterology
(1953) - et al.
Gastric antral vascular ectasia: the watermelon stomach
Gastroenterology
(1984) - et al.
Watermelon stomach: pathophysiology, diagnosis, and management
J Gastrointest Surg
(2003) - et al.
The watermelon stomach: clinical presentation, diagnosis, and treatment
Am J Gastroenterol
(1998) - et al.
Severe portal hypertensive gastropathy and antral vascular ectasia are distinct entities in patients with cirrhosis
Gastroenterology
(1995) - et al.
Gastric involvement in systemic sclerosis: a prospective study
Am J Gastroenterol
(2001) - et al.
Gastric antral vascular ectasia (watermelon stomach) in patients with ESRD
Am J Kidney Dis
(2006) - et al.
Bleeding from gastric antral vascular ectasia in marrow transplant patients
Gastrointest Endosc
(1996) - et al.
Endoscopic mucosal ablation for the treatment of gastric antral vascular ectasia with the HALO 90 system: a pilot study
Gastrointest Endosc
(2008) - et al.
Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia (watermelon stomach): long-term results
Dig Liver Dis
(2004)
Endoscopic cryotherapy for the management of gastric antral vascular ectasia
Gastrointest Endosc
The epidemiology of autoimmune diseases
Autoimmun Rev
Global estimates of the prevalence of diabetes for 2010 and 2030
Diabetes Res Clin Pract
The metabolic syndrome
Lancet
The metabolic syndrome
Lancet
Metabolic syndrome and nonalcoholic fatty liver disease: is insulin resistance the link?
Mol Cell Endocrinol
Metabolic syndrome and NASH
Clin Liver Dis
Gastric mucosal vascular ectasias causing bleeding in cirrhosis. A distinct entity associated with hypergastrinemia and low serum levels of pepsinogen I
Gastroenterology
Neuroendocrine cell proliferations in gastric antral vascular ectasia
Gastroenterology
Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis
Gastroenterology
Cited by (0)
Funding: None.
Conflict of Interest: No conflicts of interest to report.
Authorship: ES – Design, acquisition of data, and drafting of the manuscript; BT – Design, acquisition of data, and critical revision of the manuscript; JP – Analysis and interpretation, drafting of the manuscript and statistical analysis; S Cornella – acquisition of data and drafting of the manuscript; S Caldwell – Study concept, design, drafting, and critical revision of the manuscript for important intellectual content.