Clinical research studyVenous Thromboembolism in Patients Hospitalized with Nephrotic Syndrome
Section snippets
Data Sources
The number of patients, excluding newborns and infants <1 month of age, discharged from hospitals with a diagnostic code of nephrotic syndrome from 1979 through 2005 was obtained from the National Hospital Discharge Survey.24 Among these patients, the number with pulmonary embolism, deep venous thrombosis, or renal vein thrombosis was determined.
The national hospital discharge survey consists of data obtained annually from 181,000 to 371,000 sampled patient abstracts from 400 to 494 nonfederal
Results
From 1979 through 2005, 925,000 patients were discharged from nonfederal short-stay hospitals with the nephrotic syndrome and 898,253,000 patients did not have the nephrotic syndrome. Demographic information is shown in Table 1. A higher proportion of males, a lower proportion of Whites, and a higher proportion of Blacks had the nephrotic syndrome than those who did not. Ages were the same in both groups.
Among patients with the nephrotic syndrome, 0.5% had pulmonary embolism, 1.5% had deep
Discussion
The relative risks of pulmonary embolism and deep venous thrombosis were higher in patients with the nephrotic syndrome than in those who did not have the nephrotic syndrome, indicating that the nephrotic syndrome is a risk factor for venous thromboembolic disease, as had been suggested (Table 3).1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 The relative risk of deep venous thrombosis in patients with the nephrotic syndrome was particularly high (6.81) in patients aged
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Predictors of thrombosis in patients treated with bevacizumab
2022, Thrombosis UpdateCitation Excerpt :Criteria for nephrotic syndrome include proteinuria exceeding 3–3.5 g/24 h [20]. One retrospective cohort study showed that patients with nephrotic syndrome have a greater risk of PE and DVT (RR of 1.39 and 1.72) compared to those without nephrotic syndrome [21]. Another observational study of patients with intramembranous nephropathy (IMN) showed the incidence of thrombotic events (TE) in the first six months was 7.69%.
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