SYNTAX Score and Pre- and Poststent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients With Stable Angina Pectoris
Section snippets
Methods
Subjects were selected from the Massachusetts General Hospital (MGH) OCT Registry. The MGH OCT Registry is an ongoing international multicenter registry of patients who have undergone OCT of the coronary arteries at 20 sites across 6 countries (http://www.clinicaltrials.gov: NCT01110538). For the purpose of this study, we included patients presenting with stable angina who have undergone percutaneous coronary intervention (PCI; n = 247). Patients who had both optimal angiography and OCT images
Results
In the 3vessel-SS analysis, SS tertiles were defined as follows: first tertile from 2 to 6.5 points, second tertile from 7 to 11.5 points, and third tertile from 12.0 to 26.0 points. A total of 165 patients (179 lesions) were included in the analysis: 48 patients (52 lesions) in the first tertile, 59 patients (65 lesions) in the second tertile, and 58 patients (62 lesions) in the third tertile. Baseline characteristics are shown in Table 1. In 179 lesions, 100 lesions were in the LAD, 52 in the
Discussion
To our knowledge, this study is the first report investigating local plaque characteristics in relation to the degree of atherosclerosis (measured by SS) in the whole coronary tree, and plaque characteristics in relation to the lesion complexity in patients with stable angina. The main findings of this study were as follows: (1) more progressed coronary artery disease (CAD) and higher lesion complexity measured by SS is associated with higher prevalence of lipid-rich plaque and features of
Disclosures
Ik-Kyung Jang has received fellowship grant and consulting fees from Abbott.
Acknowledgment
The authors thank all the investigators and all supporting staff. Dr. Jang's research was supported by “Michael and Kathryn Park”, and by “Gill and Allan Gray.” Dr. Thomas Zanchin is supported by the Swiss National Science Foundation grant number 323530_171146. Dr. Tomoyo Sugiyama is supported in part by the grant from Strategic International Research Collaboration Program with Harvard Medical School to Cultivate Professionals with Knowledge and Humanity from Japan Society for the Promotion of
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