Oral Abstract
OP-136 Relationship Between Serum Anti-M2- muscarinic Receptor Levels and Atrial Electromechanical Delay in Patients Diagnosed with Paroxysmal Atrial Fibrillation

https://doi.org/10.1016/j.amjcard.2015.01.287Get rights and content

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Objectives

Animal studies have demonstrated that rabbits immunized against M2- muscarinic receptors (M2- R) had longer intra-atrial activation times and shorter atrial effective refractory periods. Atrial electromechanical delay (AEMD) determined with echocardiography, allows evaluating atrial electrical remodeling, which has been shown to be related with initiation and maintenance of atrial fibrillation (AF). We aimed to determine whether serum anti-M2-R levels correlated with AEMD in paroxysmal AF

Methods

35 paroxysmal AF patients with preserved left ventricular function were included in the study. Serum anti-M2-R levels were measured with ELISA. AEMD measurements were obtained from transthoracic echocardiography.

Results

35 paroxysmal AF patients with preserved left ventricular systolic function (49.6± 7.6 years, 57.2% male) were included in this study. Of baseline parameters, age (ρ=0.525, p<0.001), duration of AF (ρ =0.378, p=0.025), and left atrial (LA) diameter (ρ=0.718, p<0.001) were found to be significantly correlated with serum anti-M2-R levels. Serum anti-M2-R levels were also significantly correlated with intra-left AEMD (ρ=0.457, p=0.006) and inter- AEMD (ρ =0.415, p=0.013).

Conclusion

Findings of our study point out that serum anti-M2-R levels are significantly correlated with parameters of atrial remodeling, including AEMD and LA diameter, in paroxysmal AF patients with preserved LV function.

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