Elsevier

The Lancet Neurology

Volume 6, Issue 1, January 2007, Pages 14-16
The Lancet Neurology

2006 Round-up
Epilepsy: clinical observations and novel mechanisms

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    We previously reported a retrospective analysis in which 12 of 14 patients with presumed vaccine encephalopathy in fact had previously unrecognised Dravet syndrome, 11 of whom had mutations in SCN1A.5 This showed that vaccination was wrongly blamed as an acquired cause of a genetic disorder,20,21 and the hypothesis that vaccination was the causal factor in our cohort could be rejected. However, the possibility that vaccination triggered the onset of Dravet syndrome, causing a temporal shift (ie, brought forward an inevitable onset),22 or resulted in worse neurological outcome in these patients could not be excluded.

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