Elsevier

The Lancet Oncology

Volume 15, Issue 4, April 2014, Pages 365-366
The Lancet Oncology

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Circulating tumour cells: telling the truth about metastasis

https://doi.org/10.1016/S1470-2045(14)70091-9Get rights and content

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    During the metastasis, tumor cells, termed as circulating tumor cells (CTCs), have detached from a primary solid tumor to circulate in the bloodstream and reached another organ to form a secondary tumor. Therefore, CTCs are closely associated with tumor size, progress, metastasis, relapse and prognosis [1–4]. Analysis of CTCs in peripheral blood is important in individual treatment and prognosis of solid tumors.

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    For all these reasons, in accordance with the suggestion of Cristofanilli, the FDA and pharmaceutical industry should include the enumeration and molecular analysis of CTCs in future clinical trials, particularly when testing targeted therapies [39].

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