Contributed paperFunctional models for iron-bleomycin
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Lysosome directed red light photodynamic therapy using glycosylated iron-(III) conjugates of boron-dipyrromethene
2023, Journal of Inorganic BiochemistryRecent advances in the chemistry of iron-based chemotherapeutic agents
2020, Coordination Chemistry ReviewsMitochondria localizing high-spin iron complexes of curcumin for photo-induced drug release
2018, Inorganica Chimica ActaCitation Excerpt :We have chosen iron for this very purpose considering the oxophilicity and bio-essential nature of iron which with its rich coordination chemistry is very important for human health. The well-known clinically successful anticancer antibiotic drug of this metal is iron-bleomycin (Fe-BLM) which is a metalloglycopeptide [27]. Iron in its trivalent oxidation state forms stable chelates as catecholates and hydroxamates as found in siderophores and enterobactins [28,29].
Catalytic C-H oxidations by nonheme mononuclear Fe(II) complexes of two pentadentate ligands: Evidence for an Fe(IV) oxo intermediate
2017, Journal of Molecular Catalysis A: ChemicalMetal-based methods for protein inactivation
2013, Current Opinion in Chemical BiologyNuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity
2012, Journal of Inorganic BiochemistryCitation Excerpt :The photocytotoxicity is almost 10 times higher than their dark toxicity. There are only few reports on iron(II) complexes modeling the biological activity of bleomycins (BLMs) [29–32]. High-spin (S = 2) iron(II) complexes having pentadentate polypyridyl ligands are known to show cytotoxicity in dark giving IC50 values of 1.1 to 7.7 μM in various cancer cell lines [29].