Surface coats and secretory trafficking in African trypanosomes

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Abstract

Recent advances in transfection technology have been exploited to address fundamental questions relating to secretory trafficking in African trypanosomes. Targeted gene disruptions and ectopic expression of the major stage-specific surface proteins have provided unexpected insights into both the function and assembly of the essential parasite surface coats. A growing list of novel secretory cargo molecules, as well as advances inthe characterization of trypanosomal secretory machinery, provide a unique model system for the study of eukaryotic secretory processes.

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