Inactivation of the Dopamine Transporter Reveals Essential Roles of Dopamine in the Control of Locomotion, Psychostimulant Response, and Pituitary Function
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Cited by (16)
Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy
2011, PsychoneuroendocrinologyCitation Excerpt :Increased latency to reach a visible platform in the Morris-water maze is also found in “hyper-DAergic” mice, generated by genetic inactivation of the DA transporter (DAT) (Morice et al., 2007; Weiss et al., 2007). These mice have constitutively elevated extracellular levels of DA (Fumagalli et al., 1998; Dumartin et al., 2000) and, similarly to what we found in our present studies, display intact spatial memory (Weiss et al., 2007). DAT knock-out mice however show strong deficits in reversal learning, suggesting that the differences observed in the cued Morris-water maze could be attributed to increased preservative behavior (Morice et al., 2007) as a consequence of enhanced DA neurotransmission (Morice et al., 2007).
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems
2009, Biochemical PharmacologyCitation Excerpt :First, a DAT deficit, as opposed to a DAT absence (−/− DAT), provides for a more realistic condition that would be applicable and relevant to the clinical setting [27,28]. Second, −/− DAT mice show a marked hypopituitarism with glands being about half the size of that in normal animals [29]. Such secondary endocrine effects may confound some of the sex/hormonal parameters to be evaluated within the proposed experiments.
Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings
2009, Journal of PainCitation Excerpt :Also, some data indicate sex differences in dopamine transporter (DAT) function. This transporter plays a critical role in regulating dopaminergic function.139,448 The density of DATs are greater in female versus male rats,330,448 and clinical reports have shown greater densities of DATs within healthy adult women versus men.286,383,448
Chapter V Motor function(s) of the nigrostriatal dopamine system: Studies of lesions and behavior
2005, Handbook of Chemical NeuroanatomyAnimal models of attention-deficit hyperactivity disorder
2003, Brain Research ReviewsCitation Excerpt :DAT-KO mice can reproduce, but females show impaired maternal behavior, and their young require cross-fostering by normal dams to survive [37,98]. Changes in reproductive behavior are paralleled by loss of prolactin-producing cells in the anterior pituitary, and depressed functioning of the hypothalamus [37,96]. The coloboma mutant mouse was produced by neutron irradiation, and only the heterozygote (Cm+/−) is viable [234].