Current Biology
DispatchT-Cell Co-Receptors: The end of a frustrating search
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In addition to their antigen-specific receptors, mature T cells express essential co-receptors — one or other of the cell surface molecules CD4 and CD8, characteristic of helper and killer T cells, respectively. The CD4 and CD8 co-receptors have served as useful markers for following the sometimes tortuous pathways of thymocyte differentiation, which are outlined in Figure 1 (reviewed in [1]). The earliest T-cell precursors express low levels of CD4 and no detectable CD8 when they seed the
Christophe Benoist and Diane Mathis, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I’Inserm, Institut de Chimie Biologique, 11, rue Humann, 67085 Strasbourg Cédex, France.
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Cited by (5)
Signaling checkpoints during the development of T lymphocytes
1998, Current Opinion in ImmunologyCD4: A Co-receptor in the immune response and HIV infection
1997, International Journal of Biochemistry and Cell BiologyAsymmetric redundancy in CD4 silencer function
1996, ImmunityNegative regulation of CD4 expression in T cells by the transcriptional repressor ZEB
1999, International ImmunologyThe regulation and function of the CD4 coreceptor during T lymphocyte development
1996, Current Topics in Microbiology and Immunology
Christophe Benoist and Diane Mathis, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et Unité 184 de Biologie Moléculaire de I’Inserm, Institut de Chimie Biologique, 11, rue Humann, 67085 Strasbourg Cédex, France.