Potent, non-peptidic oxytocin receptor antagonists from a natural source
Penicillide and related compounds have been discovered to be antagonists of the peptide hormone oxytocin. Several derivatives of the natural product were prepared and its absolute stereochemistry was determined.
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Cited by (31)
A fungus-derived purpactin A as an inhibitor of TMEM16A chloride channels and mucin secretion in airway epithelial cells
2021, Biomedicine and PharmacotherapyCitation Excerpt :Since TMEM16A is also required for ASM contraction, we speculated that purpactin A may promote ASM relaxation. Previous studies reported the action of purpactin A as a strong oxytocin receptor antagonist, which consequently inhibited uterine smooth muscle contraction in rats [44]. Importantly, oxytocin promotes ASM contraction, and its receptors are upregulated upon treatment of IL-13 or TNF-α, the two cytokines involved in asthma pathogenesis [45].
The synthesis of monocyclic and bicyclic molecules and their antioxidant properties
2019, Journal of Molecular StructureCitation Excerpt :Mondal and coworkers synthesize (±)-cyclophellitol, (±)-valienamine, (±)-gabosine I, (±)-gabosine G, (±)-gabosine K, (±)-streptol, (±)-1-epi-streptol, (±)-uvamalol A, lincitol A, lincitol B, uvacalol I, uvacalol J, and uvacalol K starting from myo-inositol [19,20]. Another example, Pennicillide derivative 1, which is a lactone ring and methyl ether, has been shown to be an antagonist of the peptide hormone oxytocin as an inhibitor of the cholesterol ester transfer protein [20–24]. Lactones which are one of the biologically important molecules can also be used as antitumor agents [20].
Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.
2018, Tetrahedron LettersDibenzodioxocinones - A new class of CETP inhibitors
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1996, Comprehensive Heterocyclic Chemistry II: A Review of the Literature 1982-1995Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
2024, Revista Brasileira de Farmacognosia