The Rel family of eukaryotic transcription factors
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Cited by (43)
Dorsal regulates the expression of two phage lysozymes acquired via horizontal gene transfer in triangle sail mussel Hyriopsis cumingii
2021, Developmental and Comparative ImmunologyCitation Excerpt :The RHD is found in a family of eukaryotic transcription factors, some of which appear to form multi-protein DNA-binding complexes. The RHD consists of two immunoglobulin-like β-barrel subdomains, which adsorb DNA in the major groove (Chytil and Verdine, 1996). Phosphorylation of RHD plays a role in the activation of transcription factors, thereby regulating the expression of their target genes (Baeuerle and Henkel, 1994).
NFAT as cancer target: Mission possible?
2014, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :All NFAT proteins share a highly conserved Rel-homology domain (RHD) (Fig. 1) [25]. This domain is structurally similar to the DNA binding domain of the nuclear factor-κB (NF-κB) family [26,27]. As a unifying characteristic in all NFAT proteins, RHD endows the NFAT members with a common DNA-binding specificity [25].
The 5′ region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: Promoter characterization and alternative pre-mRNA splicing
2005, Biochimica et Biophysica Acta - Gene Structure and ExpressionRegulation of NF-κB/Rel by IκB is essential for ascidian notochord formation
2005, Developmental BiologyA biophysical characterisation of factors controlling dimerisation and selectivity in the NF-κB and NFAT families
2004, Journal of Molecular Biology
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