Phage-displayed peptide libraries

doi:10.1016/S0958-1669(98)80017-7

Current Opinion in Biotechnology

Volume 9, Issue 4, August 1998, Pages 427-436

https://doi.org/10.1016/S0958-1669(98)80017-7 Get rights and content

Abstract

Over the past year, significant advances have been achieved through the use of phage-displayed peptide libraries. A wide variety of bioactive molecules, including antibodies, receptors and enzymes, have selected high-affinity and/or highly-specific peptide ligands from a number of different types of peptide library. The demonstrated therapeutic potential of some of these peptides, as well as new insights into protein structure and function that peptide ligands have provided, highlight the progress made within this rapidly-expanding field.

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Citation Excerpt :
As compared to larger molecules such as proteins, the advantages of peptides are their lower immunogeneicity and cost of synthesis, easier diffusion towards targeted sites, as well as their greater in vivo stability. Phage display technology is one of the most frequently used screening tools for the identification of peptide ligands able to target any type of biomolecules (Smith and Petrenko, 1997; Zwick et al., 1998). This technique consists in the insertion of a foreign DNA fragment (oligonucleotide) in the structural gene of bacteriophages, which leads to the expression of a peptide at the surface of the viral particle.
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Phage-displayed peptide libraries

Abstract

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

Science

Antibody-selectable filamentous fd phage vectors: affinity purification of target genes

Gene

Searching for peptide ligands with an epitope library

Science

Random peptide libraries: a source of specific protein binding molecules

Science

Peptides on phage: a vast library of peptides for identifying ligands

Proc Natl Acad Sci USA

Tapping the immunological repertoire to produce antibodies of predetermined specificity

Nature

Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library

Mol Immunol

Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate

Biol Chem

Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage

J Mol Biol

Characterization of anti-anti-idiotypic antibodies that bind antigen and an anti-idiotype

Proc Natl Acad Sci USA

NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein

J Mol Biol

Selection of phage-displayed peptides mimicking type 1 diabetes-specific epitopes

J Autoimmun

Identification of a novel type 1 diabetes-specific epitope by screening phage libraries with sera from pre-diabetic patients

J Mol Biol

Induction of anti-carbohydrate antibodies by phage library-selected peptide mimics

Eur J Immunol

Mimotopes of polyreactive anti-DNA antibodies identified using phage-display peptide libraries

Eur J Immunol

Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrmination by peptides between closely related anti-carbohydrate antibodies

Proc Natl Acad Sci USA

Peptide inhibition of glomerular deposition of an anti-DNA antibody

Proc Natl Acad Sci USA

Peptide mimicry of adenocarcinoma-associated carbohydrate antigens

Hybridoma

Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus

Nat Biotechnol

Preparation of peptides which mimic glycosphingolipids by using phage peptide library and their modulation on beta-galactosidase activity

FEBS Lett

Peptide epitopes recognized by a human anti-cryptococcal glucuronoxylomannan antibody

Infect Immun

Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans

J Mol Biol

The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes

J Mol Biol

The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library

Proc Natl Acad Sci USA

Three-dimensional solution structure of the complex of alpha-bungarotoxin with a library-derived peptide

Proc Natl Acad Sci USA

Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display

Eur J Biochem

Using molecular repertoires to identify high-affinity peptide ligands of the WW domain of human and mouse YAP

Biol Chem

Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine

Science

Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1

J Biol Chem

Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation

Nat Biotechnol

Phage-displayed peptide targeting on the Puumala hantavirus neutralization site

J Virol

Development of antiangiogenin peptide using a phage-displayed peptide library

Cancer Res

Selection of a high affinity angiogenin-binding peptide from a peptide library displayed on phage coat protein

Mol Cells

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

Science

Alpha v integrins as receptors for tumor targeting by circulating ligands

Nat Biotechnol

Identification of novel mdm2 binding peptides by phage display

Oncogene